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Using Firefox with HTTPS Everywhere add-on, start here:

https://www.ncbi.nlm.nih.gov/pubmed/23116330

With HTTPS Everywhere enabled, click the link in the top-right corner, "Read Free Full Text at BioMedCentral"

This will lead to

http://www.biomedcentral.com:443/1756-0500/5/610/abstract

and produce this error:

400 Bad Request

Bad Request

Your browser sent a request that this server could not understand.
Reason: You're speaking plain HTTP to an SSL-enabled server port.
Instead use the HTTPS scheme to access this URL, please.

Hint: https://127.0.0.1/

---

Apache/2.2.16 (Debian) Server at 127.0.0.1 Port 443

Manually replacing "http" with "https" produces the correct page.

With the "BioMed-Central" rule in HTTPS Everywhere disabled, the link works as expected (albeit without switching to https).

I am using HTTPS-E 3.0.4 on Firefox 17.0 (Fedora 17)