diff --git a/browser/app/profile/001-base-profile.js b/browser/app/profile/001-base-profile.js
index 13ad54f2a1ac58e29888e7ba75efdd5f128cd482..2a3708c540c25a1b02b4881d3dd5dcb265ad7c2b 100644
--- a/browser/app/profile/001-base-profile.js
+++ b/browser/app/profile/001-base-profile.js
@@ -290,6 +290,11 @@ pref("browser.preferences.moreFromMozilla", false);
 pref("extensions.screenshots.disabled", true);
 pref("extensions.webcompat-reporter.enabled", false);
 
+// Disable contentRelevancy component (which itself is gated on Nimbus) (tor-browser#42867)
+pref("toolkit.contentRelevancy.enabled", false;
+pref("toolkit.contentRelevancy.ingestEnabled", false);
+pref("toolkit.contentRelevancy.log", false);
+
 pref("browser.search.region", "US"); // Disable GeoIP search lookups (#16254)
 // Disable use of WiFi location information
 pref("browser.region.network.scan", false);