Pipeline defense interferes with twitter and flickr photostreams
The Pipelining defense appears to damage flickr photostreams and twitter media streams. In both cases, these sites experience page load issues and dead images.
In brief ad-hoc testing, reducing network.http.pipelining.max-optimistic-requests to 10 seems to allow all images to load, but more testing is needed.
To upload designs, you'll need to enable LFS and have an admin enable hashed storage. More information