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BTCPayserver suggests to deploy and use the docker configuration in production.

The docker configuration is available via docker-compose: https://github.com/btcpayserver/btcpayserver-docker

BTCPay depends on several pieces of infrastructure, mainly:

A lightweight block explorer (NBXplorer),
A database (PostgreSQL or SQLite),
A full node (eg. Bitcoin Core)

There can be more dependencies if you support more than just standard Bitcoin transactions, including:

C-Lightning
LitecoinD and other coin daemons

It seems the bitcoin client needs to be installed and synced locally, therefore I am a bit concerned about storage. On this issue the docker setup has some scripts to prune the synced data to approx 100GB: https://github.com/btcpayserver/btcpayserver-docker#how-i-can-prune-my-nodes

I am also concerned how to make this setup play nicely with our infrastructure.

It would be nice if we can have an idea of the setup that BTC is currently running for us. What are the requirements? How many coins are supported?